W. Howard Roark: search on Z-Library

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1

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick M. O’Brien, Joe Nahra, Mark Morris, W. Howard Roark, Cathleen E. Hanau, Peter G. Ruminski, Jeffrey A. Scholten, Theresa R. Fletcher, Bruce C. Hamper, Jeffery N. Carroll, Willi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

2

Bioisosterism in drug design: Identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors

W. Howard Roark, Janak Padia, Gary L. Bolton, C. John Blankley, Arnold D. Essenburg, Richard L. Stanfield, Richard F. Bousley, Brian R. Krause, Bruce D. Roth

Journal:

Bioorganic & Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 922 KB

english, 1995

3

Synthesis of a chiral synthon for the lactone portion of compactin and mevinolin

Bruce D. Roth, W.Howard Roark

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 229 KB

english, 1988

4

Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond

Roark, W. Howard, Roth, Bruce D., Holmes, Ann, Trivedi, Bharat K., Kieft, Karen A., Essenburg, Arnold D., Krause, Brian R., Stanfield, Richard L.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 790 KB

english, 1993

5

ChemInform Abstract: The Preparation of Optically Active α-Amino 4H-[1,2,4]Oxadiazol-5-ones from Optically Active α-Amino Acids.

John E. Mangette, Matthew R. Johnson, Van-Duc Le, Rajesh A. Shenoy, Howard Roark, Michael Stier, Thomas Belliotti, Thomas Capiris, Peter R. Guzzo

Journal:

Year:

2010

File:

PDF, 56 KB

2010

6

α-Substituted Malonester Amides: Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity

Sliskovic, Drago R., Picard, Joseph A., O'Brien, Patrick M., Liao, Peggy, Roark, W. Howard, Roth, Bruce D., Anderson, Maureen A., Mueller, Sandra Bak, Bocan, Thomas M. A., Bousley, Richard F., Hameleh

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 198 KB

english, 1998

7

Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme

Roark, W. Howard, Tinney, Francis J., Cohen, David, Essenburg, Arnold D., Kaplan, Harvey R.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 673 KB

english, 1985

8

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

Roth, Bruce D., Blankley, C. John, Hoefle, Milton L., Holmes, Ann, Roark, W. Howard, Trivedi, Bharat K., Essenburg, Arnold D., Kieft, Karen A., Krause, Brian R., Stanfield, Richard L.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.21 MB

english, 1992

9

Inhibitors of acyl-CoA:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents

Trivedi, Bharat K., Holmes, Ann, Stoeber, Terri L., Blankley, C. John, Roark, W. Howard, Picard, Joseph A., Shaw, Mary K., Essenburg, Arnold D., Stanfield, Richard L., Krause, Brian R.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 969 KB

english, 1993

10

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

Plummer, Mark S., Cornicelli, Joseph, Roark, Howard, Skalitzky, Donald J., Stankovic, Charles J., Bove, Susan, Pandit, Jayvardhan, Goodman, Annise, Hicks, James, Shahripour, Aurash, Beidler, David, Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

11

1,2 Shift of phenyl from oxygen to carbon in a free radical

Collins, Clair J., Roark, W. Howard, Raaen, Vernon F., Benjamin, Ben M.

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 260 KB

english, 1979

12

Book reviews

Jordan, William Chester, Turley, David, Richardson, David, Sio, Arnold A., Kolchin, Peter, Cottrol, Robert J., Frey, Sylvia R., Barker, Anthony J., Roark, James L., Temperley, Howard, Ellison, Mary, O

Journal:

Slavery & Abolition

Year:

1992

Language:

english

File:

PDF, 1.96 MB

english, 1992

13

Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory

Edwards, Thea M., Morgan, Howard E., Balasca, Coralia, Chalasani, Naveen K., Yam, Lauren, Roark, Alison M.

Journal:

Journal of Visualized Experiments

Year:

2018

Language:

english

File:

PDF, 857 KB

english, 2018

14

The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids

John E. Mangette, Matthew R. Johnson, Van-Duc Le, Rajesh A. Shenoy, Howard Roark, Michael Stier, Thomas Belliotti, Thomas Capiris, Peter R. Guzzo

Journal:

Year:

2009

Language:

english

File:

PDF, 267 KB

english, 2009

15

Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo.

Bruce D. Roth, W. Howard Roark, Joseph A. Picard, Richard L. Stanfield, Richard F. Bousley, Maureen K. Anderson, Katherine L. Hamelehle, Reynold Homan, Brian R. Krause

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 206 KB

english, 1995

16

Dehydrogenation reactions of benzophenone

Vernon F. Raaen, W. Howard Roark

Journal:

Year:

1978

Language:

english

File:

PDF, 287 KB

english, 1978

17

Synthesis and Characterization of Novel Bi- and Tricyclic α-Amino Acids

Johnson, Matthew R., Gauuan, Jolicia F., Guo, Cheng, Guzzo, Peter R., Le, Van-Duc, Shenoy, Rajesh A., Hamby, James, Roark, Howard, Stier, Michael, Mangette, John E.

Journal:

Synthetic Communications

Year:

2011

Language:

english

File:

PDF, 672 KB

english, 2011

18

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo efficacy

Plummer, Mark S., Cornicelli, Joseph, Roark, Howard, Skalitzky, Donald J., Stankovic, Charles J., Bove, Susan, Pandit, Jayvardhan, Goodman, Annise, Hicks, James, Shahripour, Aurash, Beidler, David, Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1007 KB

english, 2013

19

Ethacrynic Acid as Potential Drug for Diuretic Renography in Instance of Sulfonamide Allergy

Nguyen, Ba D., Roarke, Michael C., Howard, Osborn H.

Journal:

Clinical Nuclear Medicine

Year:

2010

Language:

english

File:

PDF, 310 KB

english, 2010

20

Coal chemistry. 8. Reactions of tetralin with coal and with some carbon-14-containing model compounds

Collins, Clair J., Raaen, Vernon F., Benjamin, Ben M., Maupin, P. H., Roark, W. Howard

Journal:

Journal of the American Chemical Society

Year:

1979

Language:

english

File:

PDF, 601 KB

english, 1979

21

Additions and Corrections - Coal Chemistry. 8. Reaction of Tetralin with Coal and with Some Carbon-14-Containing Model Compounds.

Collins, Clair, Raaen, F., Benjamin, Ben, Maupin, P., Roark, W. Howard

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 90 KB

english, 1980

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